All dog, human, and animal bites should first be thoroughly cleansed with soap and water or irrigated with 100ml irrigation solution per centimeter of the wound in ER to prevent tissue cellulitis; this is the most critical step in preventing wound infection. Next, it is important to check the patient’s tetanus immunization status. Tetanus prophylaxis should be considered for all dirty wounds, especially when immunization status is unknown. For high-risk wounds, particularly large or puncture wounds, antibiotic prophylaxis is recommended, with amoxicillin–clavulanic acid as the first choice; clindamycin plus trimethoprim–sulfamethoxazole (Bactrim) may be used in patients with penicillin allergy. The length of therapy is 3–5 days if the wound is not infected and 10 days if infection develops. Additionally, if the biting animal is a stray dog or high risk animal for rabies, rabies vaccination should be considered, or local animal control should be contacted. (Reference: McConnell, J., Guiner, A., Yen, K. (2024). Emergency Medicine. In: Naga, O. (eds) Pediatric Board Study Guide. Springer, Cham)